Sabtu, 30 Maret 2019

From Particles to Men: The Origin of Life

From Particles to Men: The Origin of Life

12,000 years ago, the first human structure rose on the hills of Gobekli Tepe, Turkey, and with it the dawn of civilization. And as human advancement blooms, we began to raise questions. Important questions. And one of the most important is "how" - how did we came into being?

Image 1. Egyptian creation myth
Many theories bloomed. But first, what's a theory? Contrary to popular belief, maybe even your belief, a theory is not a hypothesis, speculation, or random guesses. A scientific theory is an explanation of an aspect of the natural world that can be repeatedly tested and verified in accordance with the scientific method, using accepted protocols of observation, measurement, and evaluation of results. Where possible, theories are tested under controlled conditions in an experiment. Many theories come, many theories go. Gone are the days of Marduk's heaven kingdom or the literal application of the biblical creation myths. This is the story of Origin, from particles to men.

The Survival of the Fittest


Image 2. Natural Selection


Evolution is change in the heritable characteristics of biological population over successive generations. These characteristics are the expressions of genes that are passed on from parent to offspring during reproduction. Different characteristics tend to exist within any given population as a result of mutation, genetic recombination and other sources of genetic variation. Evolution occurs when evolutionary processes such as natural selection (including sexual selection) and genetic drift act on this variation, resulting in certain characteristics becoming more common or rare within a population.



Image 3. The evolution of the horse is one of the most
well-documented evidence of changes over time.


The genetic mutations on living beings are completely random, and occurs all the time. The selection of what genes are passed and become more common or die out are not random, however. Nature, simply being a hard place to live, is the one and only arbiter that decides the face of lifeforms.

Image 4. Present day evolution of
pesticide-resistant pests.

The Primordial Soup

In the beginning, there was nothing. Well, except an unthinkably dense singularity which then expanded rapidly (Big Bang), formed gasses, formed stars, which went supernova, creating complex substances which then formed star systems with planets capable of harboring life, say, Earth. After the Hadean Eon ends (and you can probably tell from the name what the "Eon of Hades" earth looked like),we have these cooled down earth with simple particles floating around in the ocean - we call them the primordial soup.

Image 5. Miller-Urey experiment.
In 1952, scientists tried to replicate these pre-life conditions of earth in the groundbreaking Miller-Urey experiment. Within a few hours, the tube is covered with dark substances and when they analyze its composition, the results were astonishing. Amino acids, which were previously thought to be able to be produced by living forms, can form naturally in nature. And we have found other complex molecules in asteroids and various other places. Further experiments produced more and more complex molecules including phosphate backbone, pentose sugar, and nucleobases such as adenine. The ingredients of RNA, or at least, its analogue.

Image 6. Viroids, independent RNAs


Strains of ribonucleotide then formed naturally on the surface of montmorrilonite clay - found throughout the world - if we dry and rehydrated the sample. This process easily occur due to rain season or sea tides, and voila, we have our proto-RNA. Actually, we still have variants of them around, such as viroids. These proto-RNAs can also bend and stick with itself, creating unique structures able to produce amino acids including, for a few lucky ones, RNAs proto-RNAs capable of producing its own building blocks, giving it a humungous evolutionary advantage. Meanwhile, on hydrothermal vents below the ocean, we have found fat molecules could naturally occur from H and CO. When there are enough concentration of fat, due to its hydrophobic and hydrophilic nature they will bond together, eventually forming a kind of semipermeable layer which could bend and form a hollow ball, trapping the proto-RNAs inside - voila, proto cells! 

Unicellular Life

Image 7. Protocell metabolism
The lipid membrane was not stable however, as it can exchange fat with others. But the one with the most complex inside had the greatest capability of sucking off their peers and grew. When they grew large enough, they split - reproduction. Some lucky cell have their ribosomes mutate to form phosphate, which stopped lipid loss and enables internal evolution. For billions of years, cells continuously evolve, developing nucleus membranes, performing endosymbiosis with mitochondria, chloroplast, and other single-celled life to form a more complex cell, etc until we have a world of single-celled world of life with complex perks, such as opisthokonta (cells with flagel).

Image 8. Proterospongia
 Through mutual symbiosis, cells bond with each other. At first, this is just happen in a limited collection, but overtime they became attached and diversified their function, forming large and increasingly complex colonies. Eventually they reached a phase where they've been so intertwined that they cannot live without each other. This is Holozoa., a clade which now includes everything from mushrooms to human.




Multicellular Life 
Overtime, Holozoa evolved and diversified in accordance to environmental demands and evolutionary competitive pressures. A clade diversified to form the Metazoa, or "animals", which has the ability of:
  1. Consume organic materials;
  2. Breathe oxygen;
  3. Able to move;
  4. Reproduce sexually;
  5. Grow from blastula during embryonic development.
Separating from clades such as Porifera (e.g corals), Placozoa (multicellular Amoeba-like plate-shaped animal) and Cnidaria (e.g jellyfish), the Bilaterian clade appeared. Bilaterians are animals with bilateral symmetry, i.e they body can be divided into anterior and posterior as well as ventral and dorsal.
Image 9. Haplogonaria, a very simple Bilaterian worm.
Image 10. Lancelet, a simple Chordate
Bilaterians eventually diversified into Protostome (mouth developed first) and Deuterostome (anus developed first). Deuterostomes then diversified yet again, with the clade Chordata forming. These animals have their neurons concentrated into a chord-like structure allowing for a greater coordination. Craniate clade soon evolved, which were Chordates with skulls  giving them a defense and other advantage. Vertebrates finally evolved, who had bone tissue covering and protecting their neural chord (vertebral columns).

Vertebrate

Image 11. Placoderm fish
Some vertebrates evolved to grow jaws,. forming the Gnathostomata clade.They evolved into Placoderms, fish with plates as this is crucial especially in the highly competitive Devonian period. But eventually, some fishes lost their armored plates during the evolution while developing hard bones as opposed to cartilages. These fishes are known as Euteleostomi. Placoderms meanwhile has completely extinct in the wild today.



Image 12. Lobe fins to Amphibian



A more  developed strain of bony fishes, known as Sarcopterygii evolved with lobe fins. Devonian evolutionary pressures pushed the fishes to land, forming the Tetradomorpha clade which had four limbs. Their descendants, the Tetrapods (meaning "four foot") have, well, four limbs and colonized the land, with their most profound evolutionary change from a body breathing and navigating in water to a body enable to move on land. The first amphibians are primarily aquatic, then semiaquatic such as Amphibians, and then evolved the ability to lay egg on land (or later carry it in the womb), known as Amniotes.

Mammals

Image 13. Amniote's Procynosuchus,
the "dog-crocodile".
Branching out from Sauropsida (Reptiles and Birds) is Synapsids, and from it and Pelycosaurs (e.g. Dimetrodon) and Therapsids. These animals are warm-blooded, furry, have legs directly beneath their body, and other major differences. All Therapsids has went extinct today except a clade known as Mammals, which nursed their young with milk from their mammary glands. Most mammals are intelligent, with some possessing large brains, self-awareness, and tool use. On of the diverging clade, Therians, give birth to live young without egg (unlike other mammals e.g platypus). Most of their descendants possess epipubic bones, except Eutherians (or Placentalia as the other Eutherians had extinct), allowing the expansion of abdomen during pregnancy and its fetus developed in the uterus until a relatively late stage.

Primates

Image 14. Primate evolutionary tree.

Eutherians diverged into clades which, due to evolution, its members today has no real and easily observable differences except genetics, shared common ancestors, and other. After separating with Atlantogenata (Elephants etc.), Laurasiatherian, Rodents, Lagomorphs (rabbit etc), Treeshew, and Colugos, finally the clade Primate appears. Primate skull is large, protecting the large brain which is the characteristic of this group. They adapted to challenges in tropical forests, developing color vision, visual acuity, and are one of the most social of animals. Finally, clades diverged to Haplorrhine (whose upper lip isn't connected to the nose/gum, allowing expressions), which then diverged to Simiiformes (all monkeys), and then Catarrhine (Old World monkeys), then Hominoidea (apes), Hominidae (great apes), and the Homo genus. One surviving species, the Homo sapiens sapiens, possess the ability to use tools, fire, manipulate the environment to their needs, and share information, whether from direct vocals or even electromagnetic waves such as reading a blogpost about evolution. 

Conclusion

We are far from uncovering the whole truth. Science are based upon evidences, and we have eliminated baseless or completely misguided beliefs in favor of an explanation that explains all and is based on the scientific method. With time and effort, we are continuously one step closer to the complete picture of the Story of Origins.

Disclaimer: None of the images nor sources belong to the writer. The usage falls under the fair use principle, and its link are accessible.




Sources:

1999. Science and Creationism: A View from the National Academy of Sciences. National Academy of Sciences (US)

Miller, Stanley L. 1953. Production of Amino Acids Under Possible Primitive Earth Conditions. American Association for the Advancement of Science.

Ferris, James P. et al. 1996. Synthesis of Long Prebiotic Oligomers on Mineral Surfaces. Nature.
Al, Rushdi et al. 2006. Abiotic Condensation of Glyceride Lipids and Wax Esters Under Simulated Hydrothermal Conditions. NCBI.

Keeling, P.J. et al. 2008. Organelle Evolution: What's in a Name?. Current Biology. 

Hogg, Stuart. 2013. Essential Microbiology (2nd ed.). Wiley-Blackwell.

Allen, Robert Day. 1981. Motility

Smith, John Maynard. 1995. The Major Transitions in Evolution. W. H. Freeman and Company.

Gilbert, Scott. 2010. Developmental Biology 9th Ed + Devbio Labortatry Vade Mecum3. Sinauer Associates Inc.

Wagooner, Ben. 2011. Vertebrates: More on Morphology. UCMP.

Coates, M.I. 2009. Paleontology: Beyond the Age of Fishes. Nature.

Min, Zhu et al. 2002. Major Events in Early Vertebrate Evolution. CRC Press.

Long JA, et al. 2004. The Greatest Step in Vertebrate History: A Paleobiological Review of the Fish-Tetrapod Transition. Chicago Journals.

Romer, A. S. 1933. Vertebrate Paleontology. University of Chicago Press.

Cornelis, G. et al. 2015. Retroviral Envelope Gene Captures and Syncytin Exapcation for Placentation in Marsupials. National Academy of Sciences of the United States of America.

Pough, F. W. et al. 1979. Characteristic of Primates. Pearson.


http://www.historyrocket.com/images/Examples-Of-Natural-Selection.jpg

Rabu, 06 Maret 2019

Recommendation Letter: Irgi Arya Priambodo

From:
Dr. Zhillan Attarizal R., M.T
Headmaster of SMAN 28 Bandung
Jl. Cigadung Permadani kav.3 Bandung
140191
08166642069
zhilanar@gmail.com

To:
Prof. Dr. Fadhlan Situmorang R. M.Pd.M.T.
Representative of University of Cepat Sukses Boyolali
Jl. D.N Aidit no.6 Boyolali
420666

Assalamualaikum Wr. Wb, dear Mr. Situmorang,

I'm writing this letter to you as the go-to representative recommended by ucsb.edu. Right now, as you've stated earlier this month, in cooperation of the Supersemar Foundation, UCSB will open a scholarship program for the Faculty of Mining and Petroleum Engineering (FTTM) major.

One of my brightest student, Irgi Arya Priambodo, has requested a seat on this program. My school is a favourite school focused on education, grades, and competition. However, since the 10th grade, Irgi has shown exceptional quality in engineering and machinery, while also focusing and succeeding in his academic obligations. He has achieved many accomplishments throughout his educational history, particularly in academics.

Irgi has taught himself - a critical skill - various knowledge in engineering, based on his own aspiration. This was proven when I accompanied him to a village charity program, he was immediately stuck in a deep and very technical conversation with the guide showing us various machinery which will be used for the village's development. Irgi also won physics research competition.

He has a distinguishable skill in drawing, and I'm not talking about arts, but rather technical drawing where the talent to perceive room, quick calculation, and precision is omnipotent. He had helped his 31 friends in completing the technical drawing with exceptional results.

From my observation, Irgi truly deserves a seat in the scholarship program. His skills, passions, talent, and accomplishments simply match. As the principal of SMAN 27, I strongly recommend Irgi for the scholarship program.

Bandung, 29 February 2019. Sincerely,



Dr. Zhillan Attarizal R., M.T.
Headmaster of SMAN 28

Selasa, 05 Maret 2019

EduPASSION 2019




On January 24th, SMAN 3 conducted the Edu-Passion event. Important people came, such as West Java Governor Ridwan Kamil and others, including a student from Philippines which stayed in our class for a week or so.

Wait, what's Edu-Passion? It's a festival, if you can call it so, where university representatives came to our school and opened stands where they campaigned and promoted their university and programs. It's a great way to learn and start planning for your future. In fact, I made the decision to go to STEI ITB on that day. 

In the beginning, there was nothing. Then, around 9am, our class führer Marcho distributed the fearsome Arduous Paper - where we have to go around interviewing university representatives and put the information we got there, or else our report paper will receive a hit. Not a good thing to get in a day that basically talks about the future.

So we walked around the plaza, interview and having conversations with various people from college students to moustache man with a suspicious raunchy face. We got quite a good deal of informations, actually. On 11 am, the seminars starts and I went to the STEI room. I felt like that's the most important part of the day. 

After the seminar, I went praying, which is a shame as I missed the HI seminar. Buying the ridiculously overpriced lunch, I also got to join the FTI and FTSL seminars. It was an interesting day, and a very important day obviously. It will more fun if we had realized that the Arduous Papers was left on the table and decayed to thin air to join the annals of time. 

I think that covers much, so have a good day, eat your vegetables, and vote for Jokowi. See you around!

My Goals, My Dreams, My Future

Who's this special snowflake with internet access?
Hi! My name is Zhillan Attarizal Rezyarifin, nicknamed Zhillan. I'm a 16 y/o from Bandung, Indonesia, Southeast Asia. I have a younger sister, who is a hedonistic cinema-dweller, and a younger brother, who is a diligent and curious person although a bit passive and crybaby. I might live with them for some years in the future, as my parents moved to Jakarta to be able to earn money and buy food.

Talking about my parents, I love them both. Based on measurable and immeasurable methods. My dad's working in property development, he's loving, nice, diligent, and caring. He also have access to various kinds of people and shares his experiences with me. My mother, on the other hand, is my idol. I think you have the stereotipical loving mom in mind, don't you - caring, housewife, religious, with good cooking ability? Throw that away - my mom's a macho, independent, strong woman working in President Jokowi's infrastructure development who deals with big money, mafia, railways, steel, and problems. She is the type of person who plays with stocks and banking interests, and through her I learn various "dark skills" necessary in life - things like flattery, cheating, manipulation, etc.

How do I waste spend my time before the Certain Fate swallow us all (death)
Hobby? I like reading and worldbuilding. And I like to research and argue about politics for hours, whether in offline earth or online forums (which websites' run in foreign country with foreign laws and is therefore free from the blasphemy law, ITE, etc) as a) I like it and b) my parents' career is directly impacted by the result of the Indonesian political process - they work in infrastructure development. I also spends an unhealthy amount of time watching YouTube videos and browsing.

As school ends in 2 pm (I consider the rest 1 hour as a theft of my lifespan), I just use the next 5 hours in afterschool lesson at Daniel's Learning House, so I can actually understand the materials, get good grades, and be able to buy food in the future.

Pros and cons of this person
Strength? Well, that's quite a heavy topic. I'm going to be straight and honest here, I consider myself as a "smart" person. I consider myself to have and to like searching for a vast and open knowledge, with the ability to analyze and apply it. I believe that I'm rational and don't fall easily to unsubstantiated claims. I'm also pretty realistic and pragmatic, not bound to a particular dogma or belief, and I don't fear challenging the status quo.

However, I also belief that humans are more or less equal, and an advantage on one sector will be counteracted by a disadvantage on the other. That impacts me, too: social skills. Let's be honest, my social skills are terrible, which is horrifying considering that it's the 21th century and AI/robotic takeover of repetitive jobs are imminent. My arithmetic (not necessarily math) skill is not something to be proud of, and I'm also pretty apathetic and have little willpower. I can't speak very well, especially in the heaven-forsaken "r" letter, and I can't also for God's sake differentiate between left and right.

The value of a person depends on what value generated in his life, if not then he's just wasting government welfare
I've achieved a lot of nice academic achievements in the past, in science, math, and english, in school and competitions. Keyword: past. And by that I mean elementary school. Because you gonna shine the brightest if you're standing in a pile of coal. Yes, I compared some of my elementary peers to coal, and with scientific reason too (I looked at their IQ test), although there's other good reason (bullying and unhappy childhood). But as I climbed the social ladder and finally reached SMAN3, the level has changed, and will continue to change in the future.

Outside of measurable achievements, do I have any other achievements? Can that be considered achievements? I have good grades, with the definition of "good" predetermined by me. I have a good and loving family, who supports and care about each other. I maintained a good connection of friends, which is far better than my friends on elementary school of which some of them I compared with coal.

Dreams: a realistic targeted predictions or completely spurious fantasy-leprechaun
My imaginative dreams aren't that simple, yet I think it's great. I want the world to be a better place. No, literally - I want climate change and Hothouse Earth to be prevented by international cooperation. I want a liberal democratic world government to be established, while the people become divided on reason-based tribes (economic/political ideology, etc) whose critiques are constructive, instead of pointless identitarian factors like race, religion, cultures, nation, etc. Every discriminated minority to receive the same rights and standard. Values and policies to be judged on reason and pros and cons, instead of "X told me so" or "We've been always doing this". I wish for humanity to reach Type 1 civilization and expand to the cosmos, and merge with Technium Kingdom (AI, robots etc) instead of being genocided by it. I also want to go to space (and obviously return healthy). I want education to become widespread and the people to be able to think rationally and through the scientific method, instead of believing in a set of dogmas and ideologies set in stone.

Well, that's quite a lot to ask for, so I'll focus on what's reachable. Not easy, or rather, not too clear. Based on techno-economic trends, observation, and various judgements, my best bet will be go to engineering in a top university (ITB) and go work in a information technology company, preferably Telkomsel. But as I've stated I'm not sure that I have the right fate-given skills to do it, especially in leadership, accounting, initiative, and competitiveness. I also don't know whether my passions can be fit into that career choice. Still, this path is still my best bet though, as blindly following your passion rarely lead to success - and if we look at the top richest people in the world, all of them have a common theme: they are passionate on things that generates money.

I think that's cover a lot of things, so have a good day, eat your vegetables, and vote for Jokowi. See you around!

Rabu, 10 Oktober 2018

The Drug War: The Success That Wasn't

The Drug War: The Success That Wasn't

The War on Drugs is an international program dedicated to the prohibition and eradication of drugs and (thus) drug usage. It was started by the Richard Nixon in 1971, and became a global activity.

The United States alone spends 50 billion USD (750 Trillion Rupiah) annualy in their commitment to the war on drugs, or six times of the Indonesian military spending. The war on drugs followed a simple premise: eradicate drugs, and drug usage will go down. Yet this premise failed to consider many arguments, such as the law of basic economics. Since drugs are inelastic, addicted people will buy it no matter the cost. Therefor, when we restrict the supply, the demand and price increase to a fantastic level - fantastic for cash-strapped thugs looking for a quick buck. Thus a new industry explodes: while big factories closes, house-made decentralized drugs production flourished, and after billions of taxpayer money, the supply of drugs increased. The government then try to restrict the distribution of materials needed to produce drugs. While house drugs industries did fell, in their place rose internationally organized cartels colluding with local goverments with better equipment, drug concentration, and production lines. Thus, after billions of money, the supply of drugs increased again while the drugs itself become way more dangerous. In fact, according to a study, the war on drugs has a efficiency rate in reducing supply of 1%. We cannot win this war on the supply side, nor is it a desirable thing to aim for. This program did claim a great moral highground, but any program that costs trillions of dollars while having an efficiency rate of 1% is a bad program.

This does not account the damages the war on drugs has done to the world. In Mexico, more people died to drug-related violence than civilians who died in Iraq and Afghanistan combined. United States housed the largest prison population in the world, in the number and proportion, the majority of which came from drug-related crimes. Indonesia risks international isolation by executing foreign civilians caught in a drug crime. All in the name of a failing policy hunting a target that isn't real. This phenomenon was not new, however; in 1920s, the United States enacted a prohibition of alcohols championed by moralists. The result was a rise of gang violence and beer-producing mafias - ever heard the names of Al Capone and friends? "Licquor" also become the norm - an unregulated alcohol product with an insane ratio of alcohol in it. Beers were legalized again in 1930's during the Great Depression - arguably the worst time to have an alcohol prohibition - but the effect lasts decades.

So is there any alternatives? In the late 20th century, Switzerland faced a looming heroin disaster. They even had "needle parks" - where hundreds of junkies lay in public parks, injecting heroin to their skin. Switzerland could have prohibited drugs, but instead they pursue another solution: harm reduction. By focusing on harm reduction, addicts were brought to care centers. They were given free heroin and clean syringes, psychological assistance, and given social support to continue their lives once they stopped using drugs. Today, drugs aren't prohibited (athough still discouraged), in fact you can easily buy cannabis products in the country. But the result if the policy was astounding: drug usage fell significantly, especially compared to the country that enacted drug prohibition, with hundreds of times efficiency and way, way less cost. The policy was subsequently tried in Portugal with a resounding success.

No one argue that drug is good or has any non-medical benefit. But there are a reason why most countries legalize alcohol and tobacco. If properly regulated, drugs aren't really that dangerous - western countries isn't facing societal collapse or economic misery due to regulated alcohol and tobacco. The fact is, if we really want to reduce drug usage, reconsider other alternatives - harm reduction and prevention - than wasting more money to catch an imaginary unicorn. If not, more people will die from drugs. Imagine that.

Sources: Wikipedia, Kursgesagt.

Kamis, 20 September 2018

My Group' Wedding Card

September 19th, 2018

Hello comrades! Today, I would like to show an invitation card that we (Zhillan A.R, Irgi A.P, and Vivaldi A.S) had created last week from paper, fancy ribbons, and colored markers.

Gallery:


Here are the content of this invitation:

1. Name of the host
 According to this card, the event is jointly hosted by Mr. Phillip Rees-Hercules and Ms. Sumintem, and very likely their family too.
2. Phrase on the invitation
 We can find that the host invites the reader from the text "Mr. H. Rees-Hercules and Ms. Sumintem request your most honourable presence to attend our...".
3. The kind of event
According to this card, this event is a wedding ceremony.
4. Date
According to this card, the event will be held at Tuesday September 30th, 2069.
5. Time
According to this card, the event will be held at 04.00 pm.
6. Venue
According to this card, the event will be held in the Lubang Buaya Great Hall, near the Kasih Ibu Cemetary and the Bumi Indah Mental Hospital.
7. Special instruction
All attendees are required to bring a bucket of lily. Considering that lily simbolizes death, the reason why this flower is a requirement is beyond me.
8. Request to respond
If the reader will or will not attend, they are supposed to tell a person called Gian bin Harris Munthe.

So that is our wedding card. What do you think?

From Particles to Men: The Origin of Life

From Particles to Men: The Origin of Life 12,000 years ago, the first human structure rose on the hills of Gobekli Tepe, Turkey, and ...